Zachary A. Klase, PhD

Zachary A. Klase, PhD

Zachary A. Klase PhD

Associate Professor of Biological Sciences


BS, Cook College, Rutgers University

PhD, The George Washington University Medical Center

Research Interests

  • Human Immunodeficiency Virus
  • RNA interference
  • Immune response to viral infections


My lab focuses on the study of the Human Immunodeficiency Virus (HIV) the causative agent of Acquired Immunodeficiency Syndrome (AIDS).  HIV presents an interesting challenge for two reasons: 1) the virus integrates into the genome of the host cell and can persist for decades, 2) the viral genome is relatively small thus requiring the virus to co-opt various cellular processes to be successful. Of particular interest to me are the mechanisms that control viral replication and allow the virus to persist in the presence of therapy.  My work combines molecular biology and immunology practices to examine the interface between host and pathogen.

Selected Scholarly Activity

Klase Z, Yedavalli VS, Houzet L, Perkins M, Maldarelli F, Brenchley J, Strebel K, Liu P, Jeang KT. (2014) Activation of HIV-1 from latent infection via synergy of RUNX1 inhibitor Ro5-3335 and SAHA. PLoS Pathogens. Mar 20;10(3)

Klase Z, Jeang KT. (2013) HIV-1 envelope is sufficient to mediate super infection exclusion and is capable of pseudotyping HTLV viral particles. Virology.  Aug; 443(1):106-112

Klase Z, Sampey GC, Kashanchi F. (2013) Retrovirus infected cells contain viral microRNAs. Retrovirology. Feb 7;10(1):15

Houzet L, Klase Z, Jeang K.T, (2012) The extent of sequence complementarity correlates for the potency of cellular miRNA-mediated restriction of HIV-1 replication. Nucleic Acids Res. Dec; 40(22):11684-96

Klase Z, Houzet L, Jeang KT. (2012) MicroRNAs and HIV-1: complex interactions. J Biol Chem.  Nov; 287(49):40884-90

Klase Z, Houzet L, Jeang KT. (2011) Replication competent HIV-1 viruses that express intragenomicmicroRNA reveal discrete RNA-interference mechanisms that affect viral replication. Cell and Biosciences.  1:38

Carpio L, Klase Z, Coley W, Guendel I, Choi S, Van Duyne R, Narayanan A, Kehn-Hall K, Meijer L, Kashanchi F. (2010) microRNA machinery is an integral component of drug-induced transcription inhibition in HIV-1 infection. J RNAi Gene Silencing.  6(1):386-400.

Coley W, Van Duyne R, Carpio L, Guendel I, Kehn-Hall K, Chevalier S, Narayanan A, Luu T, Lee N, Klase Z, Kashanchi F. Absence of Dicer in monocytes and its regulation by HIV-1. J Biol Chem. 2010 Oct; 285(42):31930-43

Klase, Z.,Winograd, R., Davis, J., Hildreth, R., Heydarian, M., Fu, S., McCaffrey, T., Kashanchi, F. 2009. HIV-1 TAR miRNA protects against apoptosis by altering cellular gene expression. Retrovirology. 16;6:18

Zhou, M., Huang, K., Jung, K.J., Cho, W.K., Klase, Z., Kashanci, F., Pise-Masison C.A., Brady, J.N. Bromodomain protein Brd4 regulates HIV transcription through phosphorylation of CDK at threonine 29. J. Virol 2008 October 29

Contact Information

Office location: McNeil Science & Technology Center, Room 273
Mailing address: Box # 38
University of Sciences
600 South 43rd Street
Philadelphia, PA 19104-4495
Office Phone: 215-596-8521
Office Fax: 215-596-8710

z [dot] klase [at] usciences [dot] edu