Anil D'mello PhD

 Anil D'mello

Anil D'mello PhD

Professor of Pharmaceutical Sciences

Education

BS (Bombay)

PhD (Pittsburgh)

Research Interests

  • Protein formulation and delivery
  • Microencapsulation of enzymes

Synopsis

Dr. D’mello received his Ph.D. degree from the University of Pittsburgh and a B.Pharm from the University of Bombay. He teaches Pharmacokinetics in the Undergraduate, Professional and Graduate programs. He is the recipient of the Lindback Award for Distinguished Teaching, the American Association of Colleges of Pharmacy Outstanding Teacher of the Year award, and the USciences Founders Day Faculty Award. Dr D’mello serves on review panels of the NIH R15 and SBIR/STTR programs. He has served as primary supervisor to 13 Ph.D. students and 4 M.S. students.

The focus of the laboratory is the fabrication of proteins in polymer matrices as controlled delivery systems. We are interested in understanding the effects of manufacturing variables on protein structure and function and in the development of innovative formulation strategies to minimize adverse effects. We characterize proteins using a variety of techniques including circular dichroism, laser diffraction, enzyme kinetics, western blots, fluorescent microscopy, and protein binding. Our recent project on encapsulating phenylalanine ammonia lyase for the management of phenylketonuria has been patented and funded by an NIH STTR grant to explore its potential for commercialization.

Selected Scholarly Activity

Abdulkareem Alanezi, Steven H. Neau, and Anil P. D’mello. Development and application of a modified method to determine the encapsulation efficiency of proteins in polymer matrices. AAPS PharmSciTech. 21, 2020.

Ruchi Shah and Anil P. D’mello. Strategies to maximize the encapsulation efficiency of phenylalanine ammonia lyase in microcapsules. Int.J. Pharmaceut., 356, 61 - 68, 2008

Ruchi M. Shah and Anil P. D’mello. Stabilization of phenylalanine ammonia lyase against organic solvent mediated deactivation. Int.J. Pharmaceut., 331, 107-115, 2007

Susan Habibi-Moini, and Anil P. D’mello. Evaluation of possible reasons for the low phenylalanine ammonia lyase activity within cellulose nitrate membrane microcapsules. Intl. J. Pharmaceutics., 215: 185-196, 2001

Contact Information

Office location: Robert McNeil Graduate Study and Research Center Room 109A
Mailing address: Box 80
University of Sciences
600 South 43rd Street
Philadelphia, PA 19104-4495
Office Phone: 215-596-8941
Email:

a [dot] dmello [at] usciences [dot] edu